Our research teams achieve some remarkable things. The news page is intended to tell you about just some of those achievements.


Antibiotics research takes a surprise turn – up the M1

14 November 2016

Monday 14 November marks the start of World Antibiotic Awareness Week 2016

Researchers based in the South and East of England have been working to preserve the life of the antibiotics we have by increasing the effectiveness of when they are prescribed by family doctors and nurses.

The research began in Southampton, but through a quirk of fate moved up country to begin in Hertfordshire.

The bacteria that cause things like coughs and colds, as well as other nasty illnesses, are becoming ever more resistant to antibiotics. Bacteria are very good at adapting, and because we keep using the same antibiotics, they are finding ways to overcome them.

The World Health Organisation fears that if things continue the way they are we could run out of effective antibiotics by 2050. That would men in a generations' time minor illnesses could be much more serious, and even worse fatal to vulnerable people. In addition antibiotics used to protect people after surgery, chemotherapy or childbirth could be useless.

The last new antibiotics discovered were some 20 or more years ago, and it could take a long time before any new ones come along.

One way to prolong the use of the antibiotics we have is to reduce how much we use them. Sometimes antibiotics are prescribed because it's unclear if a chest infection or illness is caused by a virus or bacteria, so just in case they're given to a patient.

Doctors are through the work of NIHR CLAHRC Wessex getting more tools to help them understand what's causing the illness.

Often doctors, GPs and nurses can't be certain if an infection is bacterial or viral, and without that clarity they might choose to prescribe antibiotics.

Professor Michael Moore, a GP himself and a research lead for NIHR CLAHRC Wessex has been conducting research to trial something called C-Reactive Protein (CRP) testing in doctors surgeries. It works by taking a small pin prick of blood from the patient and analysing it in around 2 minutes.

The test then gives the doctor (GP) or nurse a better indication of whether antibiotics will clear up the chest infection.

Michael began his work in the South (Wessex region) but it was only through one nurse who heard about his work that it really started to take hold more than 80 miles away near Watford in Hertfordshire.

Advanced Nurse Practitioner, Liz Cross (pictured) works at Attenborough surgery in Bushey just inside the M25. She has been working in GP surgeries for a number of years and spotted Professor Michael Moore’s work and got in touch to trial CRP testing at her surgery.

"I can test people who come in with a chest infection using this test to see if antibiotics would work. They only work against a bacterial infection.

"During the winter months I must see patients with a chest infection every 15 minutes during my working day, and nearly each time I have to explain how antibiotics work or don’t work in their case. I felt there had to be something better and that’s when I spotted the CRP test research.

If patients could see the test and we could talk about antibiotics then I felt certain I could reduce the number of times they were prescribed – just in case."

Liz has now spread the scheme to other surgeries in her area, and there are another eight surgeries to the north of her patch.

Her initial work has shown that the only 8 per cent of people who came in with a chesty cough needed antibiotics.

She adds: "I’m not alone as a nurse seeing this problem. There are nursing staff like me in emergency departments, the community and hospitals who face this same dilemma. If we could all adopt this then I think we could really make an impact."


More information on CRP testing:

Reducing unnecessary antibiotic prescribing for chest infections in primary care

• GPs often prescribe antibiotics for patients with a chest infection ‘just in case’ it develops into a more serious condition like pneumonia

• Antibiotics will only be effective for patients with a bacterial infection, not if they have a virus causing the chest infection

• Antibiotic resistance is growing and predictions suggest that many bacteria will develop resistance to most common antibiotics by 2050 - there are no new antibiotics currently

• Around 700,000 people a year worldwide die because of drug resistant bacterial infections, by 2050 that figure could be 10 million

Introducing a simple blood test at GP surgeries

• We are promoting a finger-prick test for patients to help them and their GP decide if antibiotics will be effective for their chest infection

• The test takes two minutes

• The C-reactive Protein or CRP test gives GPs and patients a better indication of what might be causing the chest infection in the form of a risk rating

• It’s estimated this test could reduce unnecessary prescribing by 30%. GPs account for 80% of antibiotic prescriptions in the UK The research team aims to roll out the scheme to GPs in England, and measure the results by collecting data on prescribing behaviour

Patient and public involvement is vital to the success of the CLAHRC.

We would be pleased to hear from you if you are interested in becoming involved in our research and implementation.

How can I get involved?