Brain imaging in dementia (BRAIID): an observational longitudinal study to optimise image reporting in dementia clinical practice

Theme 2

Ageing and Dementia

Start date: 10/09/2015

End date: 31/12/2018

 

Research aims and questions:

 

The BRAIID study aimed to improve dementia diagnosis and prognosis by optimising HMPAO-SPECT brain imaging (a type of imaging that looks at brain function) through:

1.    Defining imaging patterns that indicate specific disease and future decline for the individual

2.    Assessing the utility of using patient imaging to predict dementia caregiver burden

3.    Evaluating the effectiveness and clinical impact of imaging to change diagnosis and influence clinician diagnostic certainty

 

Outputs

 

Papers:

Prosser AMJ, Spreadbury JH, Tossici-Bolt L, Kipps CM. Imaging Care Requirements: Use of Functional Neuroimaging to Predict Dementia Caregiver Burden. Dement Geriatr Cogn Dis Extra. 2018;8:180-9

 

Prosser AMJ, Tossici-Bolt L, Kipps CM. Occipital lobe and posterior cingulate perfusion in the prediction of dementia with Lewy body pathology in a clinical sample. Nucl Med Commun. 2017;38(12):1029-1035           

 

Published abstracts:

Prosser AMJ, Tossici-Bolt L, Kipps CM. The impact of perfusion SPECT imaging on clinician diagnostic confidence in dementia. Nucl Med Commun. 2019;40(4):393-453

 

Prosser AMJ, Spreadbury JH, Tossici-Bolt L, Kipps CM. Imaging Care Requirements: Use of Functional Neuroimaging to Predict Dementia Caregiver Burden. Alzheimer’s & Dementia. 2017;13(7):P494

 

Prosser AMJ, Tossici-Bolt L, Kipps CM. Predicting Alzheimer’s disease cerebrospinal fluid biomarkers using regional cerebral blood flow. Alzheimer’s & Dementia. 2016;12(7):P533

 

Prosser AMJ, Tossici-Bolt L, Kipps CM. Biomarker validated perfusion imaging pattern ranking for prediction of Alzheimer’s disease. Alzheimer’s & Dementia. 2016;12(7):P911-912

 

Oral presentations:

The impact of perfusion SPECT imaging on clinician diagnostic confidence in dementia. British Nuclear Medicine Society spring meeting 2019

 

Optimisation of dementia imaging. Clinical Research Network Wessex Neuroscience and Dementia specialty meeting 2019

 

Imaging care requirements: Use of functional HMPAO-SPECT scanning to predict caregiver burden. Southampton Medical & Health Research Conference 2017

 

The utility of perfusion SPECT imaging in dementia diagnosis. Memory Assessment and Research Centre (MARC) Research Update Day 2017

 

Optimising dementia diagnosis with HMPAO-SPECT imaging. South West Nuclear Medicine Group meeting 2016

 

The Brain Imaging in Dementia (BraIID) study. Clinical Research Network Division 4 Research Forum 2015

 

The Brain Imaging in Dementia (BraIID) study. University Hospital Southampton (UHS) Nuclear Medicine Group meeting 2015

 

Poster presentations:

Longitudinal Decline and Regional Cerebral Blood Flow Patterns in a Cognitive Impairment Sample. Alzheimer’s Association International Conference (Los Angeles) 2019

 

Imaging Care Requirements: Use of Functional HMPAO-SPECT Scanning to Predict Caregiver Burden. Alzheimer’s Association International Conference (London) 2017

 

Biomarker Validated Perfusion Imaging Pattern Ranking for Prediction of Alzheimer's Disease. Alzheimer’s Association International Conference (Toronto) 2016

 

Predicting Alzheimer's Disease Cerebrospinal Fluid Biomarkers Using Regional Cerebral Blood Flow. Alzheimer’s Association International Conference (Toronto) 2016

 

Regional HMPAO SPECT imaging abnormality predicts Alzheimer’s disease CSF biomarker status. University of Southampton Faculty of Medicine Research Conference 2016

 

Regional HMPAO SPECT imaging abnormality predicts Alzheimer’s disease CSF biomarker status. British Nuclear Medicine Society Spring meeting 2016

 

Impact of perfusion SPECT imaging in dementia diagnosis. Public Health England Wessex Dementia Collaboration Conference 2015

 

Impacts

Over 600 participants recruited to the BRAIID study, allowing both patients undergoing imaging and their caregivers or close companions the opportunity to be involved in research


Knowledge of how imaging patterns relate to caregiver burden can be used to aid identification of individuals who will place the highest burden on their caregivers, allowing early intervention of strategies to help the caregiver

 

Identification of patterns which indicate future decline can be used to identify those at highest risk of worse outcomes, aiding care provision

 

Knowledge of the clinical impact and utility of perfusion SPECT brain imaging can be used to increase imaging use in diagnostically challenging cases

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